Notes:

• It’s the final week of the fantasy regular season for most leagues. Don’t overthink your lineup decisions if you’re in a must-win game. Rely on those who got you this far.

• Kyler Murray went down with a noncontact injury in the Cardinals’ loss to the Patriots on “Monday Night Football.” That’s a tough blow to the Cardinals and fantasy owners at this point of the season.

• If you’re looking for a replacement for Murray, Trevor Lawrence is an option. He has completed 70 percent of his passes in four of his last five games and doesn’t have an interception since Week 8. Start him with confidence.

• After finishing with no touchdowns in 2021, Eagles running back Miles Sanders is second to Josh Jacobs in fantasy scoring the last three weeks. He has now scored 11 touchdowns and is locked in as a RB1 in Philadelphia’s explosive offense.

• J.K. Dobbins had a bit of a hitch in his step but still showed flashes of his old self on his way to 150 rushing yards. Gus Edwards had 13 carries as well so the touches are still being split, but if Anthony Brown is forced to start with the injuries to Lamar Jackson and Tyler Huntley, expect a healthy dose of both running backs.

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• With Lawrence surging, so are a pair of his pass catchers. Zay Jones saw 12 targets and Evan Engram had a whopping 15 targets against the Titans. Both need to be rostered.

• Other injuries of note this week: Deebo Samuel is likely out for the rest of the regular season with an ankle injury, Tee Higgins has a hamstring issue, Dameon Pierce left the stadium in a walking boot on Sunday and Jeff Wilson left his game with a hip injury.

• Thankfully, the bye weeks are over, but now we have Saturday games on the schedule. Set your lineups accordingly.

Thursday Night Game: 49ers vs. Seahawks

Sunday Night Game: Giants vs. Commanders

Monday Night Game: Rams vs. Packers

Top Pickups of the Week: Trevor Lawrence, Zonovan Knight, Isiah Pacheco, Zay Jones, Donovan Peoples-Jones, Evan Engram, Raiders D/ST

Send to the Waiver Wire: Kyler Murray, James Robinson, Corey Davis, George Pickens, Tyler Higbee

Start ‘Em:

Quarterback: Trevor Lawrence
Running Back: Isiah Pacheco
Wide Receiver: Diontae Johnson
Tight End: David Njoku
Defense: Packers

Sit ‘Em:

Quarterback: Jared Goff
Running Back: Cordarrelle Patterson
Wide Receiver: Darnell Mooney
Tight End: Foster Moreau
Defense: Buccaneers

Sleepers:

Quarterback: Brock Purdy
Running Back: Pierre Strong Jr.
Wide Receiver: Tutu Atwell
Tight End: Chigoziem Okonkwo
Defense: Browns

NFL Picks for Week 15

Weekly Pick ‘Em (Season Record: 123-82-2)
49ers (vs. Seahawks)
Vikings (vs. Colts)
Browns (vs. Ravens)
Bills (vs. Dolphins)
Saints (vs. Falcons)
Jets (vs. Lions)
Eagles (vs. Bears)
Panthers (vs. Steelers)
Cowboys (vs. Jaguars)
Broncos (vs. Cardinals)
Patriots (vs. Raiders)
Bengals (vs. Buccaneers)
Commanders (vs. Giants)
Packers (vs. Rams)

Five Picks Against the Spread (Season Record: 36-32-2)
Dolphins +7.5 vs. Bills
Jets +1 vs. Lions
Chiefs -14 vs. Texans
Jaguars +4.5 vs. Cowboys
Patriots +1.5 vs. Raiders

Five Over-Under Totals (Season Record: 43-27)
Ravens-Browns under 37.5
Dolphins-Bills over 42.5
Falcons-Saints under 42.5
Titans-Chargers over 45.5
Rams-Packers over 39.5

One Bold Prediction for the Week
Week 1: Baker Mayfield and Russell Wilson each throw for 300 yards and two touchdowns against their former team. (miss)
Week 2: Four different wide outs finish with over 100 receiving yards in the two Monday night games. (miss)
Week 3: Jalen Hurts has five total touchdowns against the Commanders. (miss)
Week 4: Lamar Jackson has more than 500 yards of offense against the Bills. (miss)
Week 5: Josh Allen finishes with more rushing yards than the entire Steelers offense. (miss)
Week 6: Josh Allen and Patrick Mahomes combine for 800 yards of total offense in a potential preview of the AFC championship game. (miss)
Week 7: Derrick Henry has three rushing touchdowns against the Colts. (miss)
Week 8: The Colts rush for more than 200 yards against the Commanders. (miss)
Week 9: Davante Adams goes over 150 receiving yards after being held to one catch in Week 8. (missed by 4 yards on 17 targets)
Week 10: Justin Fields has his first 300-yard passing game on the season against Lions. (miss)
Week 11: The Patriots’ defense forces four turnovers against the Jets. (miss)
Week 12: Tua Tagovailoa throws five touchdown passes against the Texans. (miss)
Week 13: The Jets defense holds Justin Jefferson under 55 receiving yards (FINALLY, got one!)
Week 14: The Cowboys tally more than 500 yards of total offense against the Texans. (miss)
Week 15: The Ravens throw for less than 150 passing yards against the Browns

Photo Credit: Kenya Allen/PressBox

Joe Serpico

See all posts by Joe Serpico. Follow Joe Serpico on Twitter at @JoeSerp